Cancer Prevention: New delivery systems are expected to show their talents – drug delivery system – pharmaceutical industries
By the China Pharmaceutical Association, Fudan University School of Pharmacy, pharmaceutical preparations such as the National Engineering Research Center, host of the "Fourth International Pharmaceutical Forum" recently held at Fudan University in Shanghai Zhangjiang campus, this meeting's theme is "New Drug Delivery System Research and Application ", from major domestic and international well-known pharmaceutical enterprises in pharmacy colleges and more than 500 delegates attended the meeting area, a total of 8 games and 24 of the General Assembly the report of field overflow reports, more than 30 foreign experts in the forum made excellent presentations, nearly 100 young scholars to exchange and poster display of the report.
China Pharmaceutical Academy, Vice Chairman Chen Kaixian stressed at the opening ceremony: "delivery system of pharmaceutical research is a hot and difficult, more and more facts have proven that drug activity is not only decided to give full play to the effective content and purity of ingredients, preparation has become the ideal to play an important aspect of efficacy, an old drug new drug delivery system development and utilization are often no less than its value and role of a new chemical entity drugs create. "Thus, New drug delivery systems research and application of growing concern, the use of targeted strategies, nanotechnology, smart materials, drug delivery and new features to enhance efficacy and improve drug side effects, especially developed to target tumor cells efficiently, low toxicity of new drug delivery systems, has become the world's Pharmacy, co-workers, the focus of attention. The forum on the use of pharmaceutics technology to solve targeted cancer therapy had extensive in-depth exchange of experts are trying to use all means to improve anti-tumor effects of drugs and reduced toxicity of the target, although the results of these studies still significant Sentimental, but prevention and treatment of cancer show promising prospects.
Nanoparticles Fellow, Institute of High Energy Physics, Chinese Academy of Chen Chunying
mentioned in the world, cancer is a major cause of death. Compared with the primary tumor, metastatic tumors more easily lead to death. In recent years, the development of nanotechnology in cancer therapy and clinical applications have a bright future. Physical and chemical properties of nano-materials and the size of its closely related to the drugs used for treatment, gene vectors, cytokines agent has a lot of advantages. However, the toxicity of nanomaterials potentially dangerous and has caused widespread concern in building nano-delivery systems or nano-toxicity drugs has become an important issue. Report in the General Assembly, she introduced a new method of chemical modification to make nanoparticles with both anti-tumor effect but also has anti-oxidation.
University of North Carolina, Department of Molecular Pharmacy, Professor Huang Lifu the General Assembly the report of funny and humorous. According to his introduction at the forum, they prepared a surface modified liposomes – poly-cation-DNA (LPD) or liposome – poly-cation – heparin (LPH) of the nanoparticles. Such self-assembled nanoparticles of diameter about 120 nm, siRNA encapsulation efficiency was 90%. They charge this nanoparticles intravenously to H-460 human lung tumors in nude mice, 70% to 80% of the siRNA can be delivered to the tumor. When the joint delivery of three kinds of siRNA sequence (MDM2, c-myc and VEGF), lung metastases in Cancer Genes also have been suppressed in vivo tumor decreased significantly. In the therapeutic dose, the nanoparticle in both animal models of immune toxicity are extremely rare, even on a small organ damage. Huang Lifu that the nanoparticles prescription is effective intracellular macromolecular drugs delivery system.
It is reported that each year nearly 40,000 Americans were diagnosed with brain tumors, of which 15% to 35% of pleomorphic glioma (GBM), this is the most aggressive primary brain tumor . Surgery very risky, and because of the lack of palliative response, and drug targeting and selective chemotherapy in clinical practice has little success. University of Michigan College of Pharmacy VictorChi-MinYang use of magnetic iron oxide nanoparticles, Professor (MION) as a vector for the simultaneous treatment of MRI and drug exploratory study of brain tumors. In this drug delivery system, including a MRI, magnetic targeting, prodrug, intracellular drug delivery to brain drug delivery system to overcome the barriers to achieving the MRI visualization, while the minimum dose and toxicity of drugs reach a higher anti-tumor activity. He said that, in general, and glioma-specific and does not match the performance of macromolecular drugs (eg siRNA), able to be degraded in the cytoplasm of the disulfide solution can be connected to the non-toxic, can penetrate the cell membrane low molecular weight proteins; with superparamagnetic magnetic induction and superior mobility MION, surface coated with fixed heparin on the biological compatibility of dextran, low molecular weight protein modification such drugs (LMWP-Drug) and heparin-coated MION (Hep-MION) can take advantage of the positive charge on the protein and heparin on the role of the negative electrostatic charge to form complexes. VictorChi-MinYang said preliminary test results good, now successfully – galactosidase (molecular weight 465KDa) that selectively transport macromolecules to the tumor area. He said, "This is the future of cancer treatment shows good prospects."
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