China's moisture-based film coating materials research developments – film coating, coating materials, moisture-proof – the pharmaceutical industries
In recent years, with a variety of new polymer Polymer The birth and efficient Package The successful development of clothing pot, Film coating Rapid technological development, the trend gradually replaced sugar process. China's traditional Traditional Chinese medicine Tablets, pills, granules, due to the diversity of its composition, there are strong hygroscopicity, easy lobes, mildew shortcomings. How the film coating technology to the whole extract of Chinese medicine, semi extract tablets, raw powder tablets, granules and pellets and even traditional Chinese medicine has good moisture resistance without affecting its disintegration is the development of film coating materials, an important issue. In this seminar, the national Chinese medicine Pharmacy Engineering Center, Professor Shen Ping aunt introduced them in a moisture-based film coating materials development work.
Women, according to Shen Ping-hsiang introduced, affecting moisture resistant film coating materials, coating materials, factors such as composition and formula preparation materials both. A complete film coating materials typically include a film-forming polymer, plasticizer, Pigment And Additives ( Surfactant ). To improve the material's moisture resistant, can select one or combination of several film-forming materials, the proportion of material was calculated, the experimental verification, to ensure uniform and compact film of water on the environment, and appropriate repulsive force. The use of plasticizers and other additives are introduced to improve this role. Researchers used a new type of water-based polymer and other polymer compound used to show a single polymer formulation than other coating materials, more moisture, even if the alcohol-soluble formula is no exception. Superior, it has a good breakdown performance, and by choosing appropriate surface active agent to process more fluid coating material, the production operation time.
In addition, scientific and reasonable preparation process is to guarantee fully reflect the material properties, such as materials, the stability of uniform and true color reproducibility. In the preparation process of film coating materials, how to ensure that all components of the full and proper dispersion is the key. Coating material is a compound of the formula, including insoluble particles, how these insoluble particles dispersed colloidal solution to form a stable suspension, which by spray drying process of the formation of dense layer of uniform continuous film, but also affect the final moisture product key role. By some researchers to conduct ultra-fine materials Smash , Coating of the above modification methods to achieve technical requirements, in particular mineral type filler, and by packing the micronized surface modification, improved mineral Powder And polymer compatibility, but also greatly increased the optical coating products, good effects and visual effects
On the full consideration of these two factors, the researchers developed two different moisture resistance of film coating materials? Common moisture-based film coating materials and enhance moisture TF-NMP-based film coating materials, TF -EMP, sealed in plastic bags Package , Temperature 37 , relative humidity of 75% under the same environmental and packaging medicine tablets on a number of varieties ( Rhinitis Kang, flower tablets, three gold tablets, cough stop tablets) for the experiment to study the performance of its moisture. Two moisture through the development of thin film coating materials in four varieties of the application shows that compared with the reference substance, the weight gain rate of absorption of two samples had different degrees of slowing down, the three gold tablets and cough stop-chip performance particularly noticeable.
Women Shen Ping Xiang also pointed out that formula composition and preparation processes on the moisture-based film coating materials guiding the development of some significance. Application moisture thin film coating materials for improving the Chinese Solid Preparation Moisture capacity, improve its stability (shelf-life and directly related to drugs) and reduce the requirements on the packaging condition is important. However, the slow absorption rate and drug shelf-life of quantitative data on the stability of the need for a complete test to verify. Note that, in comparing different kinds of moisture application results should be cautious, because the Chinese variety is different, the film moisture absorption capacity of the core vary greatly, and the die surface area there will be differences in the data does not have the same Er Shi basis of comparison. It also prompted development of Chinese medicine preparation for a solution coating process, the first core to the nature of the film to fully assess the understanding of how to choose the appropriate film coating materials and process parameters to meet the corresponding technical moisture resistant requirements, and can not blindly pursue the strongest moisture capacity.
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