Hydrochloric acid treatment of primary hypertension Tony Van lol new 1, 1 rece
By the Chinese Academy of Medical Sciences Cardiovascular Institute and Fu Wai Hospital, clinical drug research base, Shanghai Second Medical University, Institute of Hypertension, clinical drug research base, the Sino-Japanese Friendship Hospital, Beijing research base to carry out clinical drug hydrochloride tablets Tony Van lol (Cary stability) in the treatment of Chinese patients with essential hypertension randomized, double-blind, multicenter, parallel controlled clinical study, and 24-hour ambulatory blood pressure monitoring (ABPM), 24-hour ambulatory ECG (Holter) inspection, safety evaluation The results show that all lol Tony hydrochloride tablets clinical total effective rate of over 70%, 100 to 200 mg per day orally in two, 24-hour blood pressure can be maintained. The researchers said Tony Van lol hydrochloride in treatment of essential hypertension in China has good prospects.
It is understood that any lol Tony hydrochloride tablets chemical Co., Ltd. is Japan's imports of primary research and proprietary, Shanghai Pharmaceutical (Group) Co., Ltd. Xinyi Pharmaceutical Factory-packing, the total distribution of Guangdong Roth A Pharmaceutical Co., Ltd. with 1, 1 receptor double block of a New antihypertensive drugs. Tony Van lol Japan hydrochloride tablets in the treatment of essential hypertension clinical study (951 cases) showed that mild to moderate essential hypertension drugs on the effective rate of 62 percent, with severe hypertension was 83.3 %, and hypertension associated with renal dysfunction was 75% effective.
Carried out in China where lol Tony hydrochloride tablets in the treatment of primary hypertension study, 145 cases of the average sitting diastolic blood pressure 95 to 115 mm Hg, systolic blood pressure <180 mm Hg in the essential hypertension patients after 1 week washout period and after two weeks of placebo, 136 patients were randomized, blinded treatment period into which the control group (taking metoprolol, 100 to 150 mg / day), 68 cases were ultimately 120 patients completed 8 weeks of treatment, in which all lol Tony hydrochloride (100 to 200 mg / day, twice) of 62 cases, 58 cases metoprolol group.
Research by comparing the average diastolic blood pressure range blood pressure before and after treatment showed that all lol Tony hydrochloride tablets for 8 weeks, the average diastolic blood pressure can drop subjects 8.15 ± 6.81 mm Hg, down rate ( 10.89 ± 8.04)%, mean sitting systolic blood pressure decreased 10.26 ± 14.75 mm Hg, decreased rate of (6.38 ± 9.28)%, taking the total effective rate of 70.97%.
The study completed a total of 24-hour ambulatory blood pressure monitoring (ABPM) 50 cases, of which 26 cases were drug group, patients were age, gender was no significant difference (P <0.05). The results showed that medication before and after group comparison, a 24-hour diastolic blood pressure, systolic and mean arterial blood pressure was no significant difference; taking more after the group, Tony Van lol hydrochloride group and the control group of patients taking drugs before and after full-day, day and night diastolic blood pressure, systolic and mean arterial blood pressure have a significant statistical difference (P <0.01). Tony Van lol hydrochloride tablets twice daily oral administration of 100 grams, can be maintained 24 hours a buck.
Physical examination, 24-hour ambulatory ECG (Holter) examination, 24-hour ambulatory blood pressure monitoring studies show that oral hydrochloride tablets Tony Van lol 100 to 200 mg per day, allowing heart rate in the clinical range, but did not find drug effects AV. Medication before and after the diastolic blood pressure, systolic blood pressure difference between the two groups, 9:00 to 18:00 each time point was no significant difference, but at 7:00 to 8:00, hydrochloric acid, Tony Van lol group diastolic blood pressure, systolic blood pressure difference was significantly higher than metoprolol group (P <0.05); hydrochloride Tony Van lol group scoop-shaped group of patients 24 hours after taking the diastolic and systolic blood pressure at each time point decrease compared with before treatment, most point of time there significant difference (P <0.05), non-dipper-shaped group of patients 24 hours after taking the diastolic and systolic blood pressure at each time point decrease compared with before treatment, most point was no significant difference (P> 0.05); total ambulatory blood pressure study suggests , 24 hours after taking the diastolic and systolic blood pressure at each time point decrease compared with before treatment, most point of time were significantly different (P <0.05). Metoprolol group after taking the spoon-shaped group of patients with diastolic and systolic blood pressure at each time point decrease compared with before treatment, most point drop in blood pressure during the day was statistically significant, most point drop in blood pressure at night was no significant difference (P> 0.05) ; non-dipper-shaped group of patients at each time point 24 hours after taking the diastolic and systolic blood pressure decreased compared with before treatment, most point drop in blood pressure was no significant difference (P> 0.05); total ambulatory blood pressure study suggests that 24 hours after taking the point of the diastolic and systolic pressure was decreased before treatment, most point of time, including from 7:00 to 10:00, the fall was no significant difference
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