Can Ginseng Medicine With Food? Can Not Generalize
Folk used to say “ginseng antidote”, then the ginseng and the drug can also eat in the end? Shanghai Institutes for Biological Sciences, Chinese Academy of Nutritional Sciences, from the molecular level of the people involved in drug interactions, different drugs found in ginseng has a “positive and negative” two-way role, can not be generalized. Related Articles recently published in international academic journals, “Public Library of Science? Comprehensive” (PLOSONE), the evaluation was that the ginseng and ginseng products contribute to security.
Of ginseng, must find the active ingredients??? With the activity of single molecules. Whether participation in the Americas, Asia, participation, or participation in Siberia they truly effective ingredients are “ginsenosides.” From the molecular structure point of view, these ginsenosides middle ring is basically the same mother, but around the branch structure is different. The Food Safety Nutrition Research Centre, led by doctoral researcher Renwang Hui Hao-miao, etc., in-depth study of the 15 kinds of ginseng saponins on the impact of drug metabolism.
According to reports, ginseng saponin and how drug molecules interact, depending on the body of a “medium”??? Of drug metabolizing enzymes. As the body of an important “enzyme family”, P450 enzymes involved in drug metabolism in response to the vast majority of the body of drug almost always the first through “P450” this off. WANG Hui et al systematic review of the different ginsenosides on 5 major P450 enzymes, which five kinds of enzymes with 80%? 90% of the clinical drug combination.
They found that, when combined with different drugs with these enzymes, the enzyme activity of ginsenoside will play a different role: or activation, or inhibition. For example, the strong activity of ginsenoside??? Protopanaxadiol (PPD), on the number of P450 3A4 enzyme greater impact. When the enzyme with antiepileptic drugs “CBZ” When combined with ginsenoside can activate the enzyme, promote metabolism of carbamazepine; but when the enzyme combination of angina drugs “nifedipine”, the ginseng saponin inhibition is weak enzyme, slowing the metabolism of nifedipine. Obviously, ginseng has “two sides” must be combined with a detailed analysis of drug molecules.
This end, Wang Hui with the CAS Shanghai Study Group Study Group co-drugs Hong Liu, established ginsenoside combination with the P450 enzyme three-dimensional structure-activity relationship model can be aided by means of simulation in the micro structure and assumptions of a with drug molecules to play a role. The researchers said that in China and Asia and even the West, ginseng is not only as a nutrition Health Products , Combined with other drugs have become more popular, the theoretical models help us to understand the interaction of people participating in clinical medicine.
“Public Library of Science” Peer Review comments: people involved in drugs, combined with a long history, the study found that the ginseng saponin and its derivatives with important human drug metabolism enzyme system??? P450 enzyme activation or inhibition between the role of ginseng and related products can guide the rational use of.
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