Augmentin antibiotic that continue to be effective in this era of evolving drug resistance
Years ago, most antibiotics approved for respiratory tract infections were effective. But recently, S. pneumoniae resistance to penicillin has increased dramatically to about 20 percent nationwide – making antibiotic selection very important
Bacterial Respiratory Infections Becoming Harder to Treat. In recent years, common bacteria such as S. pneumoniae, Haemophilus influenzae and Moraxella catarrhalis that cause respiratory tract infections like ABS (Acute bacterial sinusitis) and CAP (community acquired pneumonia) have become increasingly resistant to antibiotics. Antibiotic resistance occurs when bacteria change in different ways that reduce or eliminate the effectiveness of drugs, chemicals or other agents designed to cure or prevent infections. The surviving bacteria continue to multiply in the body, possibly causing more harm. Widespread use of antibiotics promotes the spread of antibiotic resistance. According to the U.S. Centers for Disease Control and Prevention, antibiotic resistance is a serious public health problem.
Augmentin antibiotics that continue to be effective in this era of evolving drug resistance
Augmentin is a member of the beta-lactam class of antimicrobials and is made up of amoxicillin and clavulanate potassium, is an antibiotic and works by killing bacteria that cause infections. Amoxicillin belongs to a group of medicines called “penicillins” that can sometimes be stopped from working (made inactive). The other active component (clavulanic acid) stops this from happening.
Augmentin oral preparations are indicated for short-term treatment of bacterial infections at the following sites:
Upper respiratory tract infections (including ENT) e.g. tonsillitis, sinusitis, otitis media. Lower respiratory tract infections e.g. acute and chronic bronchitis, lobar and bronchopneumonia. Genito-urinary tract infections e.g. cystitis, urethritis, pyelonephritis. Skin and soft tissue infections, e.g. boils, abscesses, cellulitis, wound infections. Bone and joint infections e.g. osteomyelitis. Dental infections e.g. dentoalveolar abscess. Other infections e.g. septic abortion, puerperal sepsis, intra-abdominal sepsis. Augmentin is bactericidal to a wide range of organisms including:Gram-positive : Aerobes: Enterococcus faecalis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, *Staphylococcus aureus, *Coagulase negative staphylococci (including staphylococcus epidermidis), Corynebacterium species, Bacillus anthracis, Listeria monocytogenes. Anaerobes: Clostridium species, Peptococcus species, Peptostreptococcus. Gram-negative :
Aerobes: *Haemophilus influenzae, *Escherichia coli, *Proteus mirabilis, *Proteus vulgaris, *Klebsiella species,*Moraxella catarrhalis, *Salmonella species, *Shigella species, Bordetella pertussis, Brucella species, *Neisseria gonorrhoeae, Neisseria meningitidis, Vibrio cholerae, Pastuerella multocida. Anaerobes :*Bacteroides spp. including B. fragilis * including ß-lactamase producing strains resistant to ampicillin and amoxycillin.
Usual dosages for the treatment of infection Adults and children over 12 years Mild – Moderate infections One Augmentin tablet three times a day.
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