How Protandim affects Nrf2
What is Protandim the Nrf2 synergizer?s
Genes that produce protective and beneficial products are up-regulated: like those that produce SOD, catalase, glutathione, PON1, Heme-oxygenase1 and many more. These genes are considered survival genes.
Genes products that foster disease conditions are simultaneously down-regulated. You can want your body to create scar tissue when you have an open wound but not building up in your arteries or organs.
The Body is then able to turn on its natural defense system turned on at an optimal level aiding the body’s efforts to prevent and fight disease like levels that you had in your blood back when you were in your 20’s.
Protandim? The Nrf2 SynergizerTM, achieves the goal, long sought after by world class medical researchers, of activating Nrf2. Nrf2 is a potent protein messenger contained in every cell of the body that sends information to the cell’s DNA telling the cells of the body to produce antioxidant enzymes to protect themselves from the ravages free radical damage known as oxidative stress. Nrf2 signals the genes in the nucleus of the cell to increase production of many antioxidant proteins or enzymes. Protandim’s patented synergy of five herbs activates the Nrf2 transcription factor, which in turn acts as a molecular switch that regulates 3000 of the body’s most important genes (often referred to as survival genes); up-regulating protective genes while simultaneously down-regulating metabolic processes that are harmful to health.
Through the Nrf2 pathway Protandim up-regulates three categories of health-promoting survival genes:
antioxidant enzymes protect DNA and important cellular components against free radical damage
anti-inflammatory genes protect tissues and organs against destructive inflammatory processes
anti-fibrotic genes protect tissues and organs from abnormal fibrotic buildup; especially protective for the vessels of the heart and brain from occlusion by disease-producing plaque formation
Human clinical studies show that Protandim increases levels of anti-aging catalytic enzymes:
Superoxide Dismutase (SOD) by 30%
Catalase by 54%
Glutathione by 300%
As a result, oxidative stress (free-radical damage) is reduced an average of 40-70% in just 30 days.
Reactive oxygen species (ROS) can damage biological macromolecules and are detrimental to cellular health. Electrophilic compounds, xenobiotics and antioxidants are sources of reactive oxygen species, creating oxidative stress that can harm cells. Enzymes are involved in the Phase II detoxification of xenobiotics to reduce cellular stress include glutathione transferases, quinone reductase, epoxide hydrolase, heme oxygenase, UDP-glucuronosyl transferases, and gamma-glutamylcysteine synthetase. Expression of these genes protects cells from oxidative damage and can prevent mutagenesis and cancer. Transcription of these enzymes is coordinately regulated through antioxidant response elements (AREs). Nrf2 (NF-E2-related factor 2) and Nrf1 are transcription factors that bind to AREs and activate these genes. Inactive Nrf2 is retained in the cytosol by association a complex with the cytoskeletal protein Keap1. Cytosolic Nrf2 is phosphorylated and translocates into the nucleus in response to protein kinase C activation and Map kinase pathways. In the nucleus, Nrf2 activate genes through AREs by interacting with transcription factors in the bZIP family, including CREB, ATF4 and fos or jun. Nrf2 activation of genes is opposed by small maf proteins, including MafG and MafK, maintaining a counterbalance to Nrf2 and balancing the oxidation level of the intracellular environment.
Gene Logic, inc.
Dustin Slade, Acupuncturist
Online Business and Marketing Coach
http://dustinslade.com/blog/abc-primetime-time-video-and-follow-up-about-protandim
720-301-8696
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