Insufficient amount of harm caused by bacteria resistant variant big / chart – a
Is a class of antibiotics is widely used clinical drug, in China, antimicrobial drug unreasonable application of the phenomenon is more serious, such as the lack of indications for antimicrobial use, multi-drug combination, large doses, the dose is inadequate. Among the most prominent is the large doses, but most easily overlooked is the amount of shortage. In particular, some commonly used antibiotics in patients who are either afraid of antibacterial drugs Adverse reactions , Or the fear of bacterial resistance, antibiotic use blindly reduce the time and dosage, the results to the other extreme of irrational drug use.
Bacterial infection occurs when bacteria in the human body than larger groups of these bacteria reproduce by division, each division will have a few bacteria mutate into resistant variant from the Mingan Jun bacteria. In natural conditions, the proportion of resistant bacteria minimal variation, with a large number of Mingan Jun coexist in the human body to maintain balance.
Use of antibiotics, if an adequate dose of antibiotic, Mingan Jun and individual resistance mutations can be kill bacteria, infection can be controlled. However, if the lack of antimicrobial drug dosage, drug concentration in vivo reach the level required to kill bacteria, bacteria can not be removed, infection can not control. More serious is the lack of antimicrobial drug dosage is easy to induce bacterial resistance, resistance mutations to bacteria in the human body together, to subsequent treatment difficult.
Insufficient antibacterial medicinal mainly in three aspects. First, reduce the medication dose. Some patients in the use of antimicrobial drugs, the medication dosage will be reduced arbitrarily, such as a change and a half tablets, a key change Banchi, resulting in insufficient dose of antibiotics. Second, to extend the time between taking. For example, for upper respiratory tract infection, doctors often give patients were treated with penicillin, 3 times for adults one day, and some were arbitrarily changed to one day twice, or even 1 day 1. Third, reduce the drug treatment. Most have a clear use of antibiotics treatment, typically with 5 to 7 days, but some patients symptoms improved 3 days after the unauthorized withdrawal, resulting in insufficient dose antibiotics.
Be noted that in clinical settings, the recommended dose of antibiotic is mostly set for the young, so people still need some special care to use antibiotics. Children's immature body organs, to avoid the use of some drugs are harmful to children. At the same time the dose of antibiotics for children can not be simply measured by adult conversion, be adjusted according to the situation of children themselves. Gradually diminished organ function of older persons, especially liver and kidney functional status as young adults, if the inappropriate use of antimicrobial drugs will increase organ recession affect life expectancy. And because drug metabolism is slow, the elderly need to reduce the use of antimicrobial agents, or extending the interval between drugs. Other things, liver and kidney dysfunction should avoid the use of a large ring Esters , Tetracyclines, prudent use of piperacillin, azlocillin, Cephalosporin Risperidone, erythromycin and other drugs; kidney dysfunction should avoid the use of aminoglycosides, prudent use of penicillin and cephalosporins.
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